Before we explore the cancer treatment protocol so successfully practised since 1987 by Drs Nicholas Gonzalez and linda Isaacs, I would like to first describe Cancer and the immune system
Cancer and the immune system
As I described in my original cancer series of articles our own cells including immune cells consist of a unique genetic identification marker referred to as MHC (Major Histocompatibility Complex) proteins which act as a fingerprint that immune system cells can read to decide if cells are friend or foe. This is the identification system that the immune system uses in its decision process to attack and reject organ transplantation which is the reason immunosuppressive drugs are prescribed paralysing the immune system and opening the door to any infection of the host. In addition, when the gut dysfunctions, where, if you remember most of our immune system cells reside, the immune system dysfunctions leaving it incapable of reading the ‘barcode’ MHC proteins so it begins to attack our own tissues which occurs in autoimmune diseases.
Trophoblast immune cell cooperation
During the early human reproduction process the embryo and its associated placenta ((trophoblast ) consists of foreign cells that originate from the sperm of the father, but the immune system of the mother is prevented from attacking them, in fact the trophoblast releases messenger cytokines into the mother’s bloodstream requesting the presence of white blood cell lymphocytes including its regimen of T&B cells used to recognize non-self or foreign antigens and the phagocytic Natural killer cells to reside in the decidua ( uterine lining (endometrium) during a pregnancy, comprising the maternal part of the placenta. What is surprising is that these lymphocytes would normally destroy the foreign cells of the trophoblast, but they simply stand guard preventing against any pathogens basically protecting the embryo/trophoblast assembly from harm. How does this happen ??.
The Trophoblast and cancer have the ability to ‘cloak’ themselves by disabling their own MHC Class I & II proteins that are responsible for antigen presentation on their cell surface to elicit an attack response by the immune system. Furthermore, the trophoblast secretes a series of immune modulating molecules ( e.g interleukin 10, an anti-inflammatory cytokine known as human cytokine synthesis inhibitory factor) which have a disabling effect on immune system lymphocytes. Timing is everything since the trophoblast can only invade when the endometrium is at its most receptive, between day 20-24 of the ovulatory cycle. At this same precise time, in an act of molecular mimicry, endometrium cell adhesion molecules (integrins) appear around the trophoblast allowing both endometrium integrins and the endometrium like cells around the trophoblast to meld together. The final invasive maneuver is to assure the survival of the embryo/trophoblast assembly by establishing a blood supply with the mother’s blood stream.
Establishing a blood supply to ensure embryonic survival
Once the trophoblast has established implantation it must now with haste establish a blood supply for it to develop. This early placenta ( trophoblast) must penetrate the various barriers of the uterine lining which includes first the cell-cell cadherins (calcium dependent adhesions proteins) that act as glue to bond cells together in a tight junction structure. Secondly the basement membrane is the second barrier to breach. This membrane consists of interwoven protein fibers and collagen ( the substance that maintains our skin elasticity) and as Dr Gonzalez puts it ‘like microscopic barbed wire’. In order for this series of ‘drill downs’ to be successful, the trophoblast requires the assistance of the epithelium ( the endometrium consists of a single layer of epithelium and the stroma (supportive tissue of the epithelium that consist of connective tissue and blood vessels) lining the cavity of the uterus.
Epithelium cooperation initiated by the Immune system
This epithelium cooperation is initiated by the immune system lymphocyte cells who synthesis Vascular Endothelial Growth Factor (VECF) which is an angiogenic substance allowing for new blood vessel growth, not unlike wound healing. As in wound healing, the trophoblast signals its own DNA to synthesis Matrix Metallo (Zinc)proteinases (MMP’s), a specific digestive enzyme that will melt away the various barriers of the uterus as described above. In a magnificent display of ‘dynamic reciprocity’ ( a term coined by Paul Bornstein et al in 2011 in conjunction with wound healing) that refers to bidirectional interaction between cells ( trophoblast and endometrium cooperation) that occurs between the trophoblast MMP and the extracellular matrix (ECM) of the endometrium. While the MMPs are digesting the multiple barriers of the epithelium, the integrins on the ECM attach themselves to the trophoblast membrane assisting the trophoblast to advance in establishing its blood supply. The final connection is made into the mother’s blood vessels by the secretion of VECF and other growth factors secreted by the trophoblast Fibroblast Growth Factor (FGF) and Placental Growth Factor (PGF) working together to complete the angiogenesis process.
During embryonic development stem cells that originate in the yolk sac, which gives rise to the embryo as part of the natural mammalian reproduction process, in the same way as in other mammalian creatures, fish, and land animals as confirmed by years of study by the embryologist John Beard. However, the embryonic stem cells divide rapidly, mature into the trophoblast and a fully differentiated fetus. During the lifespan of the individual, nests of stem cells that are dispersed throughout the body are used for tissue replacement. What we know is that the liver is only 5 months old, the heart about 20 years old, blood cells 120 days, lung surface 2-3 weeks (deeper parts about a year ), skin 2-4 weeks at any given time, while the entire bone structure in the body takes around 10 years to be completely replaced. Brain cells are also replaced as does the synaptic wiring, but the frequency for the former is unknown because it was always thought that brain cells were never replaced ( why would would the body replace everything else and not brain cells ? ). We change our synaptic wiring constantly depending on new thoughts, new memories, pain control. We ourselves have the power to change our synaptic wiring.
From Beard’s indefatigable research, and the research of Drs Stetler Stevenson and Kleiner, Drs Murray and Lessey, and Ferretti we can conclude that it is the stem cell whose purpose it is for tissue replacement, that, through various signals and triggers ( e.g Inflammation) activates, giving rise to prolific cell division that we call cancer. In Beard’s words it is an irresponsible trophoblast aberrantly growing in the wrong place at the wrong time. In terms of its development it is cancer development that is identical to embryonic development except that cancer can develop anywhere whereas the trophoblast has to implant itself in one place, the uterus.
Invasion of cancer mimics the trophoblast invasion of the uterus
As described above the multiple tissue invasion of the the cell-cell cadherin, the basement membrane and the stroma is also carried out by the cancer, and again dynamic reciprocity occurs where the host cells including the resident immune cells assist the invading cancer in establishing itself. Because of the aberrant and unnatural growth of cancer, tumor suppressant pathway transcription factors such as STAT3, and immune system regulators such as NF kB ( Nuclear Factor Kappa B ) play a role in triggering the stem cell to express cancer. In reality, however, the body is only adapting to the non favourable conditions accommodated by the host. It is hypothesised by Dr Russell Blaylock, retired professor of neurosurgery from the University of Mississippi that the initiation of the NF kB inflammatory pathway converts the Macrophage M1 antitumor Macrophage into a macrophage M2 pro-tumor, by TGF-ß, ( a transforming growth factor cytokine ) promoting tumor growth as opposed to suppression ( what it is designed to do). In his hypothesis he also draws attention to the MMP (Matrix Metalloproteinases) digesting enzymes as described earlier.
A systemic toxic/inflammatory host environment : ideal conditions to stimulate cancer
Since a toxic, inflammatory, high reactive oxygen species (ROS) environment, is unfavorable to the body as a whole, and since there is a strong association with chronic inflammation at the eruption of cancer, it would make sense that cancer can become systemic quite rapidly. and ignite anywhere in the body, especially when the first tumor establishes access to the host blood supply giving cancer cells a transport highway to proliferation. Furthermore, given the embryonic science outlined by Dr Gonzalez, that both trophoblast uterine implantation and cancer ignition are assisted in their quest for invasion by immune cells and Dr Blaylock’s statements that immunosuppressive macrophages are converted to pro-tumor immune cells ( paralysing their natural killer design) by initiating the pro-inflammatory pathway NFkB, I would question how effective is the immune system is toward tumor growth when under threat by an unfavorable systemic host environment. I would submit that since the whole body has been driven to imbalance, this also compromises the correct natural function of the immune system. I would conclude as did Kelley all those years ago that the first line of defence in a very imbalanced cancerous body are pancreatic enzymes ( that have to be orally taken since the pancreas is probably also compromised preventing its normal function) not the immune system. What does the Chemo wielding physician do…suppress the immune system.
Prevention and successful treatment of cancer
Dr Blaylock’s study highlights the following natural substances that have powerful inhibitory effects on tumor growth. These include resveratrol, curcumin, quercetin, hesperidin, luteolin, apigenin, naringenin, ursolic acid, and silymarin. What consumables contain these substances :
Resveratrol: a natural phenol found in grape skins ( wine), blueberries, raspberries, mulberries
Curcumin : a natural phenol found in Turmeric spice that is used in curry powder
Quercetin : a plant polyphenol or flavonol (flavonoid) * and is part of the Rutin phenolic compound family that are found in many plant based foods including Capers, buckwheat, black olives, asparagus,raspberry, plum,blackcurrant, tomato, prune, fenugreek, majoram, grape zucchini, apricot, grape
Hesperidin : is referred to as a flavonol and like Rutin has a family of various substances, but Hesperidin is specifically contained in Peppermint, orange, lemon, lime, grapefruit
Luteolin : is a flavone (type of flavonoid) found in celery, broccoli, green pepper, parsley, thyme, dandelion, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, orange and oregano
Apigenin : Another flavone found in celery, celeriac, chamomile tea, cloves, peppermint, red wine, artichokes, spinach
Naringenin : is a flavanone ( another type of flavonoid ) found in a variety of herbs and fruits that include oregano, water mint, grapefruit, bergamot orange, cherry, tomatoes, cocoa, drynaria (basket fern)
Ursolic acid : is a pentacyclic triterpenoid ( hydrocarbon chemical substance ) found in rosemary, apples ( rich in the apple peel), bilberries, cranberries, pears, peppermint, lavender, oregano, basil, thyme and prunes.
Silymarin : is a flavonoid directly extracted from milk thistle seeds, but trace amounts are found in dark skinned grapes, beet greens, black cohosh ( type of flowering plant), peanuts, brewers yeast, and most berries.
*Bioflavonoids ( flavonoids ) are plant anti-oxidants and are referred to as polyphenols. Rutin and Hesperidin are regarded as essential bioflavonoids. Flavonols are a subclass of flavonoids that provide plants UV protection and contribute to their various colors. Flavanones is another type of flavonoid that contain a sugar component called glycosides such as pinocembrin ( which is strictly speaking part of the Hesperidin family of flavonols) that is found in honey, propolis ( a kind of glue produced by bees to seal unwanted spaces within the hive, that can be consumed like honey or bee pollen and contains similar health properties). Isoflavones are estrogenic and the richest source is soy, but I would avoid consuming any type of soy except if it is fermented like soy sauce, tempeh or natto.
‘If you research wikipedia they state that for most of the compounds above there is no proof that they provide any health benefits including anti-cancer properties, but they also say nothing about the dangers of chemotherapy and radiation, so we will let them go on believing in their own delusions.’
The modern day cancer practice of Dr Isaacs
Dr Linda Isaacs and Dr Gonzalez opened up their practice in 1987 treating many patients suffering from cancer, most that had undergone conventional treatment of chemotherapy and radiation without success. As a last desperate effort to save their lives prospective patients are lucky enough to find the existence of the Isaacs practice. Some people are extremely sick when they visit this ‘last hope’ practice who are generally accepted, despite the extensive damage incurred by the poisonous chemotherapy, radiation and surgery and the majority get well. In my opinion, this practice in saving so many lives, and reversing the damage incurred by conventional modalities is nothing short of miraculous and I always said that the indefatigable selfless efforts of Isaacs and Gonzalez, both doctors should have been nominated the Nobel Prize for medicine. I also hope that when Linda retires she has somebody to pass the mantle to continue this invaluable, life saving treatment.
This unique team basically carried on the legacy of Dr Kelley using the same type of treatment protocol of individualised diet and supplement routines, large doses of proteolytic enzymes and coffee enemas. This practice is saving so many lives that have been left behind by conventional oncology,, where even Stage IV cancer patients are still alive 25-32 years out. Some skeptics are in disbelief, and ask the obvious question ?.
if it’s so successful why isn’t conventional medicine using it ?…because it does not generate any money of significance, and large profits which seems to be more important than saving lives.
The Autonomic Nervous System (ANS) and the importance of balance
During the course of seeing so many cancer patients Dr Kelly found that parasympathetic dominance in an individual tended to ignite carcinomas such as Hodgkinson’s, lymphomas, leukemia, myeloma; basically blood cancers derived from the bone marrow from an unbalanced PH that was too alkaline. On the other hand, sympathetic dominance was more associated with the solid tumor variety of malignancy such as Pancreas,lung, breast, colon,stomach where the individual was too acidic. He further observed that a person’s particular phenotype was also associative to a particular ANS branch dominance. For example Parasympathetics lean more toward a creative personality; they do not really excel in school, not terribly sociable, whereas Sympathetics have a more dominant nature, and tend to be leaders or managerial types that wake in the morning ready to rule the world. In terms of diet, Parasympathetics tend to thrive on meat, whereas sympathetics tend to thrive on plant food. Whatever state a person is in has a huge effect on homeostasis and biological balance, so diet and nutrients play a major part in maintaining balance. Designing individualized diets was a means to redress the balance of those who were dominant either way, culminating into more alkalizing food in the diet for sympathetic dominance and more acidic foods for the Parasympathetics. Balanced individuals who ate basically anything ( not processed or junk food) in moderation tended not to get cancer.
Kelleys’ Nutritional regimen to treat cancer
Kelly’s treatment was divided into 3 parts, individualised diet, Nutritional supplements/enzyme supplements and detox
Kelly originally designed 10 basic diets, although there were only ‘3 dietary phenotypes’, however the dietary expansion addressed the dominant extremities. I continue to listen to nutritional experts who still advocate a plant based diet and plenty of raw vegetables with very little if any protein from animal products, also supporting a one fits all paradigm. I believe this is fallacious. Weston A Price who spent 7 years touring the globe and observing many civilisations never found one that were only plant eaters, and yet here we are, western nutritionists advocating the ideal human diet for everybody, a plant based diet. To balance our physiology we must eat a balanced diet, plenty of vegetables & fruit, some nuts and seeds and some animal products like eggs, dairy and meat. We are as individual and unique as our fingerprints with a common substrate of function. This means that we all digest and metabolise our food the same way but its the effect that food and nutrients have on our individual bodies that varies. In other words, food that can alkalize a body, the same food can acidify a body, because of various factors that behave differently.
Common ANS Dominance affect civilisations in certain regions
You could almost say that people need individualized diets, not one-fits-all diets, but there is certain common ground, obviously, but each person needs to be assessed individually in order to fine tune all of their physiological functions so as they ‘purr’ like a Rolls Royce Silver cloud. According to Kelley, this dominance factor spreads across civilizations and the regions they inhabit, stating that sympathetic dominance is common in civilizations living in tropical climates in South America,Africa,Asia and Australia and jungles living off mainly plant based food ((approx 80%) with occasional meat ( approx 20%). The opposite is true for civilizations that live in the Northern hemisphere such as northern Europe and the colder regions of Asia and the Americas, Canada,, who are mainly parasympathetics eating a mainly meat diet with occasional plant foods.
Extreme dietary conditions
There are some civilisations that thrive on extreme diets due to the availability of food within the regions they inhabit, for example the Maasai who reside in Kenya and Tanzania survive almost entirely on a diet of raw milk, meat and animal blood consuming between 600-2000 mg of cholesterol/day ( We had better tell the medical profession so they can immediately prescribe statins for everybody in this region..lol). The eskimo hunt and eat caribou, seals, walruses, polar bears, arctic hares, musk oxen, ptarmigan birds and fish such as arctic char,salmon and whitefish at least for 10 months of the year. In the summer months they gather a few plant foods such as berries, grasses, tubers, roots and seaweed. In addition they eat meat that have been preserved which invites bacterial species to feast on the meat, so as consequence the bacterial metabolites are actually additional carbohydrates that the Eskimo consume. So the traditional Eskimo have some carbohydrates in their diet. Despite what is thought to be a perfect all meat diet providing perfect health is not actually true since the high levels of protein can eventually give rise to inflammation in some and the development of atherosclerosis.
Cellular Oxidation ( Fast/slow/mixed Oxidisers)
William Wolcott who worked with Kelly devised a method of classifying individuals metabolic needs based on cellular oxidation ( cellular mitochondria convert nutrients into energy using the citric acid or Krebs cycle that convert energy from the oxidation of acetyl-CoA produced from Carbohydrates, Proteins and fats). Cellular oxidation, like the ANS defines 2 oxidiser types ‘Slow oxidisers’ ( individuals who burned nutrients slowly ) and ‘Fast Oxidisers’ ( individuals who burned nutrients fast ) with a third category, ‘mixed oxidisers’. Furthermore, although cellular oxidation is due in part to environmental and inherited circumstance, diet is a fundamental influence. So what does this mean in practice ?. Fast oxidisers burn food fast so they need ‘slower burning fuel’ like protein rich food and fat included in every meal, not a diet rich in carbohydrates, grains and seeds as the slow oxidizer can survive on.
Kelley also figured out using his own experiences what nutrients were more suitable for the 2 dominant branches. Kelley spent many months with IBM consultants devising a computer program that would assist in the evaluation process consisting of some 3200 questions to determine dominance. Although today hair sample analysis and Heart variability tests carried out by licensed chiropractors can divulge pretty much the same thing. I have recreated the following details on sympathetic/parasympathetic dominance in terms of diet and supplementation:
Type 1 Sympathetic Dominants
Sympathetic Dominant Metabolizers most often need supplementation that includes: Vitamin D; Vitamin K; Ascorbic Acid; Biotin; Folic Acid; Vitamins B1, B2 and B6; PABA; Niacin; Potassium; Magnesium; Manganese; Zinc; Chromium; Hydrochloric Acid; Pancreatic Enzymes and Amino Acids. Kelley also observed that sympathetic dominant type one metabolisers in general were also slow oxidisers burning their carbohydrate intake slowly which the body uses fairly efficiently, but blood sugar levels remain steady. They are by and large vegetarian dominant and very rarely crave meat except for fish, but when they do consume meat they feel a loss of energy. They can normally tolerate whole grain bread, pasta etc, milk eggs, and do well on nuts,seeds and most green leafy vegetables and fruit.
Type 2 Parasympathetic Dominants
Parasympathetic dominant metabolizers most often need supplementation that includes : Vitamins E and B-12; Niacinamide, Pantothenic Acid, Choline, Inositol, Calcium, Phosphorus, Calcium Ascorbate, Bioflavonoid Complex, Zinc and Ribonucleic Acid. These metabolizers should eat at bedtime enough to carry them through the night. They should not eat leafy green vegetables or take large quantities of the B vitamins. Kelley also observed that Parasympathetic dominant Type two metabolizers possess a rapid carbohydrate burn so much so they can develop hypoglycemia — low blood sugar. Eating fruits, vegetables and sweets, fluctuations in blood sugar and energy occur several times during the day. These metabolisers have to consume meat; fatty, heavy, purine meat including lamb, beef, salmon, and sardines. Fast oxidisers that are generally the parasympathetics slow their metabolism by the consumption of fatty meat and their blood sugar and energy levels do not fluctuate. They also handle well root vegetables, cabbage, Brussels sprouts, cauliflower, carrot juice, and beans, cream and butter and small amounts of grains.
The second part of the program involve high doses of Pancreatic digestive enzymes depending on the cancer and its severity, patients would take 100-150 enzymes spread throughout the day. This program would typically last 6 months to 1 year depending upon patient compliance of the program and the severity and how advanced the cancer was. Enzymes are crucial proteins to speed up many biological processes such as metabolism and energy production within the cells. They are also crucial to our digestion where everyday the pancreas releases enzymes into the small intestine to help our digestive function. Compared to other digestive enzymes, the enzymes used in the practice of Dr Isaacs are a special blend that are prepared in New Zealand as per the specifications that Dr Gonzalez designed based on 3 years of work to mimic the way the pancreas stores its enzymes (i.e 80% precursor in fat).
The third part of program involves detoxifying the body. As you can imagine, once the enzymes commence digesting the tumor, there is a lot of dead tumor debris floating around in the body that can make the body very toxic so it needs to be expelled as soon as possible. Kelly, due to his brilliant deduction ability ‘”I think we may have our culprit Watson”. while going through his own health struggle, noticed that once the enzymes began to work he felt sick and nauseous, and then he figured out that maybe the waste from the dead tumor was making his body sick. While in the Library he found an old Merck manual that described detoxification using coffee enemas, explaining that coffee taken orally stimulates the adrenals, but taken rectally stimulates the Liver to detoxify ( Since the liver is responsible for some 500 functions this detox simulation perhaps prioritizes its detoxification activity) through the Vagus nerve. So this was added to his regimen.
If you or a friend or a family member that has cancer I would recommend contacting Dr Linda Isaacs on her website: http://www.drlindai.com/
Although I wrote 4 articles on cancer last year, I wanted to revisit the subject, since it is the most feared human condition, because some aggressive cancers like adenocarcinoma ( one form of pancreatic cancer ) and inflammatory breast cancers kill within months of their diagnosis, so it is vital that you act quickly. Once, any one of the hundred or so cancers have taken hold in the body and ignited in multiple locations drop everything and contact Linda Isaacs who with her colleague Dr Gonzalez ( who unfortunately passed away in July 2015) have saved hundreds of lives of those that were left behind by conventional medicine. The treatment program is completely non toxic ( providing you stimulate the liver in expelling the toxic fallout from enzymatic destruction of the tumour(s) using the coffee enema routines) and I believe the first year cost is approximately $US 10-12,000 which is substantially reduced for subsequent years if your particular cancer requires this length of treatment. It is important to understand that this nutritional protocol is not temporary since it must be considered a dietary change for life and the enzymes would provide protective benefit for the rest of your long life. Unfortunately, these costs are not reimbursable from any government or insurance so its out of your own pocket, but the options are clear..spend your own money or take a credit line with your bank or die early ( my apologies for being so blunt ) but it is what it is.
SO IF YOU RECEIVE A CANCER DIAGNOSIS..DO NOT FEAR THERE IS SUCCESSFUL TREATMENT BUT IT REQUIRES SOME LIFESTYLE AND DIETARY CHANGES.
Check out the previous article:
- The Trophoblast and the Origins of Cancer Drs Nicholas Gonzalez & Linda Isaacs book 2009
- Resveratrol, curcumin, quercetin, hesperidin, luteolin, apigenin, naringenin, ursolic acid, and silymarin, Wikipedia
- Nutrition and the Autonomic Nervous System Nicholas Gonzalez 2017
- Metabolic typing William Wolcott
My name is Eric Malouin
In terms of my heritage I am not a thoroughbred, I am half English from England and half French Canadian from Quebec. Having spent the last 10 years in Medical research I thought that it was time to share my passion for true health to anybody interested in maintaining health without using conventional medicine. Once in the distant past I lived off conventional grocery shelves until you visit the man in the white coat and then a light shines through the darkness that you had not realized you were in… I was in..the twilight zone….I cured my own problems using natural methods, although they were not a big deal since I have always exercised..jogging every morning and tennis 12 hours/week, swimming but I was eating a lot of devil food that was causing my body to become unbalanced..an easy fix..reprogrammed my taste buds and gave the food back to the devil…lol
I hope you enjoy the articles……